Report Guidance: Genetic disorders are those caused by mutations in DNA. Individuals born with a genetic disorder may potentially face a great deal of suffering throughout their life. Couples may be reluctant to have a child if one or both parents are carrying a genetic mutation that may affect their offspring. Genetic disorders include: cystic fibrosis, sickle cell anemia, Huntington′s disease, hemophilia, Leigh syndrome, Stargardt disease, Hunter′s syndrome A range of technologies have been developed to treat and even potentially cure these disorders, either pre- natally or post-natally, such as: gene therapy (either in-vivo or ex-vivo, pre or post- natal), gene editing, personalized medicine (also known as pharmacogenetics and pharmacogenomics), three-parent babies, enzyme replacement therapy, bone marrow stem cell transplants, induced pluripotent stems cells and genetic screening of embryos. Complete a report planning sheet (notes/bullet points) and then write a 1000 word report which addresses all of the points (a-c) below. Please refer to the grading rubric for the points below. Part 1 . a) Briefly explain some reasons for, and problems associated with one specific inherited genetic disorder (choose from those listed above). Include diagrams, flow charts, tables, graphs etc. . b) Scientific solution. Explain one way in which science may be used to treat, cure or prevent this genetic disorder. You may consider current and/or potential future solutions, but should choose and explain one solution only, from those listed above. . c) Effectiveness of solution. How effective and/or feasible is your scientific solution? Does it have significant advantages over other strategies? What are the disadvantages or limitations? Part 2 d) Identify a factor (moral, ethical, social, economic, political, cultural, environmental) that will be impacted by your scientific solution. Discuss and evaluate the implications of your scientific solution by giving a range of arguments from different viewpoints, including your own opinion where appropriate. Points you might consider include (but are not limited to): Gene therapy might be very expensive and therefor not available to everyone. Gene therapy is unnatural and is messing with nature. Personalized medicine might be more expensive than regular medicine and therefore not available to everyone. Long term side effects of gene therapy or personalized medicines are not known. Genetic information may become public when it should be kept private. Embryos with a disorder may be destroyed or aborted. Doctors can screen embryos for genetic illnesses – should they be allowed to modify embryos to ′improve′ them and created ″designer babies″?